How does dapsone work in immune thrombocytopenia? Implications for dosing.

information and only inclusion of first-degree relatives and patients born after 1936). In summary,we found survival to be similar in familial and sporadic MPN patients. With increasing knowledge on the genetic basis of MPNs, screening of family members of MPN patients with the aim of identifying patients early in the disease course may soon be possible. Early detection and preventive measures may decrease the rate of thromboembolic complications. We recommend that family history of MPNs should be incorporated in the clinical workup of MPN patients. However, until we gainmore insight regarding the potential genetic and clinical differences, clinical management should not differ between familial and sporadic MPN patients.